ACADIA HOME | SITE SEARCH | E-MAIL SEARCH

Research Articles


Home

Chemistry Department

Courses Taught

Research

Research Group

Publications

Positions Available

Research Funding

Chemistry Links

Contact Us

 

 

Dr Amitabh Jha, M.Sc., Ph.D. (Delhi)


Research Articles: (underline indicates research trainees)

74.

Jha A*, Mohapatra PP, AlHarbi SA, Jahan N. Curcumin: Not so spicy afterall. Mini-Reviews in Medicinal Chemistry, accepted  (2016).

73.

O'Brien M, Weagle, R, Corkum D, Kuanar M, Mohapatra PP, Jha A*. Convenient access to 5-arylisoindolo[2,1-a]quinolin-11(6aH)-ones. Molecular Diversity, in press  (2016).

72.

Mukherjee C, Mohapatra PP, Youssef D, Jha A*. Optical enrichment in enzyme-catalyzed resolution of 1-aryl-2,2-dimethyl-1,3-propanediols. Canadian Journal of Chemistry, in press, (2016).

71.

Al-Jaroudi Z, Mohapatra PP, Cameron TS, Jha A*. Expedient and diastereoselective synthesis of substituted 6,6a-dihydroisoindolo[2,1-a]quinolin-11(5H)-ones. Synthesis, 48, 4477-4488  (2016).

70.

Al-Jaroudi Z, Mohapatra PP, Jha A*. Facile synthesis of 3-substituted isoindolinones. Tetrahedron Letters, 57, 772-777  (2016).

69.

Bhullar KS, Jha A, Rupasinghe HPV*. Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chemico-Biological Interactions, 242, 107-122  (2015).

68.

Jha A,* Duffield KM, Ness MR, Ravoori S, Andrews G, Bhullar KS, Rupasinghe HPV, Balzarini J. Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors. Bioorganic and Medicinal Chemistry, 23, 6404-6417  (2015).

67.

Abdelkhalik AM, Paul NK, Jha A*. Concise synthesis of 12a-methyl-11-aryl-1,2-dihydrobenzo[f]pyrrolo[1,2-a]quinolin-3(12aH)-ones as racemic 14-azaestrogen analogs. Steroids, 98, 117-113 (2015).

66.

Potter E, Jha M, Bhullar K, Rupasinghe HPV, Balzarini J, Jha A*. Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors. Bioorganic and Medicinal Chemistry, 23, 411-421 (2015).

65.

Jha A*, Yadav Y, Naidu AB, Rao VK, Kumar A, Parmar VS, MacDonald WJ, Too CKL, Balzarini J, Barden CJ, Cameron TS. Design, synthesis and bioevaluation of novel 6-(4-hydroxypiperidino)naphthalen-2-ol-based potential selective estrogen receptor modulators for breast cancer. European Journal of Medicinal Chemistry, 92, 103-114 (2015).

64.

Paul NK, Jha M, Bhullar K, Rupasinghe HPV, Balzarini J, Jha A*. All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics. European Journal of Medicinal Chemistry, 87, 461-470 (2014).

63.

Mathur D, Prasad AK, Cameron TS, Jha A*. Novel approach to 3,3-dimethyl-4-morpholino-3,4-dihydro-coumarins via hetero-Diels-Alder reaction. Tetrahedron, 70, 5608-5618(2014).

62.

Jha A*, Chou T-Y, ALJaroudi Z, Ellis BD, Cameron TS. Aza-Diels-Alder Reaction between N-aryl-1-oxo-1H-isoindolium ions and tert-enamides: Steric effects on reaction outcome. Beilstein Journal of Organic Chemistry, 10, 848-857 (2014).

61.

Jha A*, Naidu AB, Abdelkhalik AM. Transition metal-free one-pot cascade synthesis of 7-oxa-2-azatricyclo[7.4.0.02,6]trideca-1(9),10,12-trien-3-ones from biomass-derived levulinic acid under mild conditions. Organic & Biomolecular Chemistry, 11, 7559-7565 (2013).

60.

Pericherla K, Jha A, Khungar B, Kumar A*. Copper-catalyzed tandem azide-alkyne cycloaddition, Ullmann type C-N coupling, and intramolecular direct arylation. Organic Letters, 15, 4304-4307 (2013).

59.

Pericherla K, Kumar A, Jha A*. Povarov-reductive amination cascade to access 6-aminoquinolines and anthrazolines. Organic Letters, 15, 4078-4081 (2013).

58.

Bhullar KS, Jha A, Youssef D, Rupasinghe HPV*. Curcumin ands its carbocyclic analogs: Structure-activity in relation to antioxidant  and selected biological properties. Molecules, 18, 5389-5404 (2013).

57.

Jha A*, Chou T-Y, Vaughan D. An efficient and expeditious synthesis of novel 2,2-dialkyl-2,3-dihydrobenzofurans from phenols and 2,2-dialkylacetaldehydes. Molecular Diversity, 17, 261-270 (2013).

56.

Vaughan D, Naidu AB, Jha A*. One-pot annulation of 2-naphthol analogs to heterocycles. Current Organic Synthesis, 9, 613-649 (2012).

55.

Yadav Y, MacLean ED, Bhattacharyya A, Parmar VS, Balzarini J, Barden C, Too CKL, Jha A*. Design, synthesis, and bioevalaution of novel candidate selective estrogen receptor modulators. European Journal of Medicinal Chemistry, 46, 3858-3866 (2011).

54.

Jha A*, Mukherjee C, Prasad AK, Parmar VS, Vadaparti M, Das U, De Clercq E, Balzarini J, Stables JP, Shrivastav A, Sharma RK, Dimmock JR. Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore. Bioorganic and Medicinal Chemistry Letters, 20, 1510-1515 (2010).

53.

Huang P-JJ, Potter E, Jha A*. Novel and convenient synthesis of 1-(pyridinylmethyl)-2-naphthols and 1-(pyridinylmethylene)-2-tetralones from 2-tetralones. Molecular Diversity, 14, 393-400 (2010).

52.

Mukherjee C, MacLean ED, Cameron TS, Jha A*. Enzyme-assisted kinetic resolution of novel 2-naphthol Mannich bases. Journal of Molecular Catalysis B: Enzymatic, 62, 46-53 (2010).

51.

Huang P-JJ, Jha A*. Synthetic approaches to 3H-naphtho[2,1-b]pyrans and 2,3-dihydro-1H-naphtho[2,1-b]pyrans. Journal of Heterocyclic Chemistry, 46, 1098-1106 (2009).

50.

Youssef D, Potter E, Jha M, DeClercq E, Balzarini J, Stables JP, Jha A*. Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents. Bioorganic and Medicinal Chemistry Letters, 19, 6364-6367 (2009).

49.

Vaughan D, Jha A*. Convenient synthesis of novel 2,2-dialkyl-1,2-dihydronaphtho[2,1-b]furans. Tetrahedron Letters, 50, 5709-5712 (2009).

48.

Huang P-JJ, Cameron TS, Jha A*. Novel synthesis of 2,2-dialkyl-3-dialkylamino-2,3-dihydro-1H-naphtho[2,1-b]pyrans. Tetrahedron Letters, 50, 51-54 (2009).

47.

McDonald GR, Hudson AL, Dunn SMJ, You H, Baker GB, Whittal RM, Martin JW, Jha A, Edmondson DE, Holt A*. Bioactive contaminants leach from disposable laboratory plasticware. Science, 322, 917 (2008).

46.

Huang P-JJ, Youssef D, Cameron TS, Jha A*. Microwave-assisted synthesis of novel 2-naphthol bis-Mannich bases. Arkivoc, xvi, 165-177 (2008).

45.

Jha A*, Huang P-JJ, Mukherjee C, Paul NK. A convenient one-pot synthesis of 2,2-dialkyl-2,3-dihydro-1H-naphtho[2,1-b]pyrans. SynLett 3127-3130 (2007).

44.

Youssef D, Nichols CE, Cameron TS, DeClercq E, Balzarini J, Jha A*. Design, synthesis and cytostatic activity of novel cyclic curcumin analogs. Bioorganic and Medicinal Chemistry Letters, 17, 5624-5629 (2007).

43.

Jha A*, Mukherjee C, Rolle AJ, DeClercq E, Balzarini J, Stables JP. Cytostatic activity of novel 4'-aminochalcone-based imides. Bioorganic and Medicinal Chemistry Letters, 17, 4545-4550 (2007).

42.

Jha A*, Mukherjee C, Prasad AK, Parmar VS, DeClercq E, Balzarini J, Stables JP, Manavathu EK, Shrivastav A, Sharma RK, Nienaber KH, Zello GA, Dimmock JR. E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-  4-piperidones: a topographical study of some novel potent cytotoxins. Bioorganic and Medicinal Chemistry, 15, 5854-5865 (2007).

41.

Paul NK, Dietrich L, Jha A*. Convenient synthesis of 1-arylmethyl-2-naphthols. Synthetic Communications, 37, 877-888 (2007). Highlighted in ChemInform, 38, 103 (2007).

40.

Duffield KM, Jha A*. 3,5-Bis(arylmethylene)-4-piperidone derivatives as novel anticancer agents. Indian Journal of Chemistry, 45B, 2313-2320 (2006).

39.

Nichols CE, Youssef D, Harris RG, Jha A*. Microwave-assisted synthesis of curcumin analogs. Arkivoc, XIII, 64-72 (2006).

38.

Jha A*, Zhao J, Cameron TS, DeClercq E, Balzarini J, Manavathu EK, Stables JP. Design, synthesis and biological evaluation of novel curcumin analogs as anti-neoplastic agents. Letters in Drug Design & Discovery,  3, 304-310 (2006).

37.

Jha A*, Paul NK, Trikha S, Cameron TS. Novel synthesis of 2-naphthol Mannich bases and their dynamic NMR behaviour. Canadian Journal of Chemistry, 84,  843-853 (2006).

36.

Prasad AK*, Mukherjee C, Sharma D, Rastogi S, Jha A, Olsen CE, Parmar VS. Synthesis and lipase-catalyzed resolution studies on novel (±)-2-(2-acetoxyethyl)-4-arylmethyl-3-oxo-3,4-dihydo-2H-1,4-benzoxazine-6-carboxylates. Journal of Molecular Catalysis B: Enzymatic, 40, 101-110 (2006).

35.

Jha A, Dimmock JR*. 1-N-(Arylmaleamoyl)-3,5-bis(phenylmethylene)-4- piperidones: a novel class of antimycobacterial agents. Pharmazie, 61, 562-563 (2006).

34.

Jha A*. Unusual synthesis of 1-(4-fluorobenzyl)-N-(1-(1-(4-fluorobenzyl)-6-  isopropoxy-1H-benzo[d]imidazol-2-ylpiperidin-4yl(-6-isopropoxy-1H-benzo[d] imidazol-2-amine. Arkivoc, I, 13-20 (2006).

33.

Ma G, Jha A*. A practical guide for buffer-assisted isolation and purification of primary, secondary and tertiary amine derivatives from their mixture. Organic Process Research and Development, 9, 847-852 (2005).

32.

Jha A*, Beal J. Convenient synthesis of 12H-benzo[a]xanthenes from 2-tetralone. Tetrahedron Letters, 45, 8999-9001 (2004).

31.

Jha A*, Dimmock JR. Convenient, tandem and one-reaction vessel synthesis of mixed 1-alkyl-2-alkoxynaphthalenes from 2-tetralone. Canadian Journal of Chemistry, 81, 293-296 (2003).

30.

Jha A*, Padmanilayam MP, Dimmock JR. Conversion of substituted 1-arylidene-2-tetralones to 1-arylmethyl-2-alkoxynaphthalenes: An example of facile aromatization. Synthesis, 463-465 (2002).

  Publications of Dr Jha as a Doctoral or Postdoctoral Trainee  
29.

Stepkowski SM, Kao J, Wang M-E, Tejpal N, Podder H, Furian L, Dimmock J, Jha A, Das U, Kahan BD, Kirken RA*. The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities. Journal of Immunology, 175, 4236-4246, (2005).

28.

Jha A, Dimmock JR*. Synthesis of 4-(3,5-dibenzylidene-4-oxo-piperidin-1-yl)-  4-oxo-but-2-enoic acid arylamides as potential cytotoxic agents. Synthetic Communications, 33, 1211-1223 (2003).

27.

Dimmock JR*, Jha A, Zello GA, Sharma RK, Shrivastav A, Allen TM, Santos CL, Balzarini J, DeClercq E, Manavathu EK, Stables JP. 3,5-Bis  (phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: a novel group of cytotoxic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 18, 325-332, (2003).

26.

Parmar VS*, Sharma NK, Husain M, Watterson AC, Kumar J, Samuelson LA, Cholli AL, Prasad AK, Kumar A, Malhotra S, Kumar N, Jha A, Singh A, Singh I, Himanshu, Vats A, Shakil NA, Trikha S, Mukherjee S, Sharma SK, Singh SK, Kumar A, Jha HN, Olsen CE, Stove CP, Bracke ME, Mareel MM. Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds. Bioorganic and Medicinal Chemistry, 11, 913-929 (2003).

25.

Dimmock JR*, Jha A, Zello, GA, Allen TM, Santos CL, Balzarini J, DeClercq E, Manavathu EK, Stables JP. Cytotoxic 4’-aminochalcones and related compounds. Pharmazie, 58, 227-232 (2003).

24.

Dimmock JR*, Jha A, Zello GA, Quail JW, Oloo EO, Nienaber KH, Kowalczyk ES, Allen TM, Santos CL, DeClercq E, Balzarini J, Manavathu EK, Stables JP. Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds. European Journal of Medicinal Chemistry, 37, 961-972 (2002).

23.

Dimmock JR*, Jha A, Kumar P, Zello GA, Quail JW, Oloo EO, Oucharek JJ, Pasha MK, Sharma RK, Allen TM, Santos CL, Manavathu EK, DeClercq E, Balzarini J, Stables JP. Cytotoxicity of 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds. European Journal of Medicinal Chemistry, 37, 35-44 (2002).

22.

Dimmock JR*, Kumar P, Jha A, Quail JW. Synthesis and cytotoxicity of 1-phenyl-3,3-diacetoxy-1-propene. Pharmazie, 56, 744-745 (2001).

21.

Parmar VS*, Singh SK, Prasad AK, Jha A, Kumar A, Jennings KR. Mass fragmentation pattern of (Z)-2-(5-arylpyrazol-3-yl)-3-arylacrylonitriles. Indian Journal of Chemistry, 39B, 915-920 (2000).

20.

Jha A, Malhotra S, Parmar VS, Errington W . 6-Hydroxy-2,2-dimethyl-3,4-  dihydro-2H-benzo{b}pyran. Acta Crystallographica C56, 899-900 (2000).

19.

Parmar VS*, Sharma SK, Malhotra S, Jha A, Errington W, Howarth OW, Puar M. Biocatalytic resolution of racemic 6-acetyl-3,4-dihydro-3-hydroxy-7-  methoxy-2,2-dimethyl-2H-1-benzopyran. Indian Journal of Chemistry 38B, 1231-1233 (1999).

18.

Gupta S, Jha A, Prasad AK, Rajwanshi VK, Jain SC, Olsen CE, Wengel J, Parmar VS*. A new amide, N-cinnamoylpyrrole and other constituents from Piper argyrophylum. Indian Journal of Chemistry 38B, 823-827 (1999).

17.

Parmar VS*, Jha A, Bisht KS, Taneja P, Singh, SK, Kumar A, Poonam, Jain R, Olsen CE. Constituents of the yew trees (Review). Phytochemistry 50 1267-1304 (1999).

16.

Jha A, Malhotra S, Parmar VS, Errington W*. 6-Acetyl-3,4-dihydro-2,2- dimethyl-2H-benzopyran-3,7-diyl diacetate. Acta Crystallographica C54, 361-363 (1998).

15.

Parmar VS*, Jain SC, Bisht KS, Sharma NK, Himanshu, Gupta S, Prasad AK, Jha A, Poonam, Malhotra S, Sharma SK, Bracke ME, Errington W, Olsen CE, Wengel J. Synthesis and anti-invasive activity of novel 1,3-diarylprop-2-enones. Indian Journal of Chemistry 37B, 628-643 (1998).

14.

Parmar VS*, Jain SC, Jha A, Kumar N, Kumar A, Vats A, Jha HN, Mukherjee, S, Singh SK, Jennings KR, Summerfield SG, Errington W, Olsen CE. Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyrans and comparative EIMS behavior of biologically active 3,5-disubstituted pyrazoles and isoxazoles. Indian Journal of Chemistry  36B, 872-879 (1997).

13.

Parmar VS*, Jain SC, Bisht KS, Jain R, Taneja P, Jha A, Tyagi OD, Prasad AK, Wengel J, Olsen CE, Boll PM. Phytochemistry of the genus Piper (Review). Phytochemistry 46 597-673 (1997).

12.

Raj HG, Gupta S, Biswas G, Singh S, Singh A, Jha A, Bisht KS, Sharma SK, Jain SC, Parmar VS*. Chemoprevention of carcinogen-DNA binding: The relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of Aflatoxin B1-DNA binding in-vitro. Bioorganic and Medicinal Chemistry 4, 2225-2228 (1996).

11.

Singh SK, Prasad AK, Olsen CE, Jha A, Jain SC, Parmar VS, Wengel J*. Neolignans and alkaloids from Piper argyrophylum. Phytochemistry 43, 1355-1360 (1996).

10.

Parmar VS*, Bisht KS, Singh A, Jha A. Chiral discrimination by hydrolytic enzymes in the synthesis of optically pure materials. (Review). Proceeding of Indian Academy of Sciences: Chemical Sciences 108 575-583 (1996).

9.

Tyagi OD, Prasad AK, Wengel J, Boll PM, Olsen CE, Parmar VS, Sharma NK, Jha A, Bisht KS. Neolignans from Piper schmidtii and reassignment of the structure of schmiditin. Acta Chemica Scandinavica 49 142-148 (1995).

8.

Parmar VS*, Bisht KS, Malhotra A, Jha A, Errington W, Howarth OW, Tyagi OD, Stein PC, Jensen S, Boll PM, Olsen CE. A benzoic acid ester from Uvaria narum. Phytochemistry 38 951-955 (1995).

7.

Parmar VS*, Jain R, Sharma SK, Vardhan A, Jha A, Taneja P, Singh S, Vyncke BM, Bracke ME, Mareel MM. Anti-invasive activity of 3,7-dimethoxyflavone in-vitro. Journal of Pharmaceutical Sciences 83, 1217-1221 (1994).

6.

Jha A, Bisht KS, Parmar VS*. Potentially useful lipase-catalyzed transesterifications (Review). Proceeding of Indian Academy of Sciences: Chemical Sciences 106 1191-1202 (1994).

  Book Chapters, Technical Reviews and Non-refereed Articles  
5.

Youssef D, Nichols CE, Jha A*. Efficient and environmentally benign synthesis of bis-Mannich bases of 2-naphthol. Polyphenol Communications, 267-268 (2006).

4.

Paul NK, Dietrich L, Jha A*. Novel synthesis of 1-arylmethyl-2-naphthols via Mannich reaction followed by reductive deamination. Proceedings of International Congress of Chemistry and Environment, 673-677 (2005).

3.

Jha A*. ChemOffice Ultra 2002: ChemDraw, ChemFinder, BioAssay, E-Notebook (Invited Review). ChemNews.Com, 12, 18-19 (2002).

2.

Parmar VS*, Jha A. Chemical constituent of Taxus species (Book Chapter). Studies in Natural Products Chemistry Ed. Atta-ur-Rehman, Elsevier Science BV, Amsterdam, The Netherlands 20 79-133 (1998).

1.

Jha A, Bisht KS, Parmar VS*. Scenario of research at doctoral and post-doctoral levels in India vis-à-vis in developed countries (Invited Review). Research Training for Development Ed. EW Thulstrup, Roskilde University Press (Denmark) 33-42 (1996).

     

Published by: Amitabh Jha, PhD
Comments to: amitabh.jha@acadiau.ca
Last revised: May 24, 2011
URL: http://www.acadiau.ca/~ajha

Acadia Home
© 2009 Dr Amitabh Jha. All Rights Reserved.